High-resolution Magnetic Resonance Imaging of Intracranial Atherosclerotic Plaques in Ischemic Stroke

Recruiting now

Conditions studied: Stroke, Intracranial Atherosclerosis, High Resolution Magnetic Resonance Imaging

In brief

Intracranial atherosclerotic disease is the most common cause of ischemic stroke in Asia, also in China. Currently, despite vascular recanalization therapy, statins are one of the main drug choices for treating atherosclerotic plaque. High resolution magnetic resonance imaging (HRMRI) can accurately assess the status of intracranial and extracranial arterial plaque, and has high consistency with histopathology. Thus, HRMRI technology has been widely used to monitor the efficacy of drug treatment for atherosclerotic plaque in clinical trials or practice. As a non-invasive technique, HRMRI make it possible to assess the morphologic characteristics of vascular wall and plaque composition of intracranial artery in vivo. It can quantitative analysis including components such as lipid-rich necrotic core, fiber cap thickness, intra-plaque hemorrhage, calcification, etc. Therefore, it is crucial for evaluating the etiology of ischemic stroke and developing secondary prevention strategies. At present, there is a lack of large-scale and prospective study to evaluate the etiology of ischemic stroke including cryptogenic stroke based on HRMRI. In this context, this study aims to establish a multi center HRMRI database of intracranial arteries among Chinese patients with ischemic stroke.

Key facts

Study ID: NCT05897645
Run by: General Hospital of Shenyang Military Region
People needed: 2110
Starts: 2023-01-19
Expected to finish: 2026-01-30
Last updated by the study team: 2025-08-21

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

1. Patient age ≥40 years
2. Time of stroke onset: within 2 week
3. Baseline NIHSS score ≤16
4. Ischemic stroke confirmed by head CT or MRI
5. Premorbid mRS ≤1
6. The degree of stenosis of extracranial arteries including internal carotid artery, vertebral artery on the lesion side ≤50%
7. The culprit plaque or possible culprit plaque with plaque burden of 40% or more found by HRMRI in the proximal part of the middle cerebral artery M1 segment or basilar artery of ipsilateral lesion
8. Signed informed consent

You may not qualify if…

1. Intracranial hemorrhage found by head CT
2. Had a contraindication to MRI,or could not complete required MRI sequences
3. Intracranial tumor, arteriovenous malformation, or aneurysm
4. Comorbidity with any serious diseases and life expectancy is less than one year
5. Pregnancy
6. Patients not suitable for this clinical studies considered by researcher

Where it is running

Department of Neurology, General Hospital of Northern Theater Command — Shenyang, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.