Oxandrolone Multiligament Knee
Paused · Phase 4 · Has a placebo group
Conditions studied: Ligament Tear Knee
In brief
This study is about healing after a rmultiligament knee reconstruction procedure. We hope to learn if a biologic medication: Oxandrolone, a synthetic derivative of the human hormone Testosterone (the principal male sex hormone and an anabolic steroid), given for 12 weeks is effective in aiding in the healing process and restoring muscle mass.
Key facts
- Study ID
- NCT05893069
- Run by
- George F. Hatch
- People needed
- 60
- Starts
- 2023-07-01
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-03-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with MRI proven multiligament knee injury scheduled to undergo multiligament knee reconstruction
You may not qualify if…
- Patients with prior ipsilateral knee surgery
- Untreated diabetes mellitus
- Pituitary tumor
- Rheumatoid Arthritis
- Uncontrolled hypertension
- Congestive Heart Failure
- Myocardial Infarction within the past 6 months
- End-stage renal disease
- Liver enzymes two times the normal value
- DVT within the past 6 months
- Disorder of the coagulation system
- Currently taking anticoagulation
- Prior or current use of anabolic steroids
- Chromosomal disorders
- Prostate cancer
- Breast cancer
- Hypercalcemia
- Patients with COPD not responsive to bronchodilators
- Patients with known liver disease
- Patients at risk for liver tumors
- Severe hyperlipidemia
- Patients taking medications that interfere with testosterone production or function, including but not limited to 5α-reductase inhibitors, acetaminophen (Tylenol, others), cholesterol lowering
Where it is running
- Keck School of Medicine of the University of Southern California — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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