Watermelon Dose Response Blood Pressure Study
Completed · Not applicable · Has a placebo group
Conditions studied: Pre-hypertension, Cardiovascular Diseases
In brief
1. Primary outcome: To evaluate the dose response effects of watermelon flesh in regulating Blood Pressure (BP) in individuals with pre-hypertension. 2. Secondary outcomes: To study the dose-response effects of watermelon flesh intake on cardio-metabolic risk factors including plasma metabolic markers, lipid profile and nitrate/nitrite levels in individuals with pre-hypertension.
Key facts
- Study ID
- NCT05892328
- Run by
- Clinical Nutrition Research Center, Illinois Institute of Technology
- People needed
- 39
- Starts
- 2023-04-07
- Expected to finish
- 2025-09-01
- Last updated by the study team
- 2026-05-29
Who can join
Age: 25 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Individuals who are nonsmokers
- Healthy overweight/ obese man or woman between 25 and 65 years of age
- Blood pressure 120-160 mmHg systolic or 80-100 mm/Hg diastolic at screening visit
- Fasting blood glucose concentration between 100 mg/dL and 125 mg/dL at screening visit (value range indicate prediabetes, by finger prick and/or venous blood sampling)
- Have no clinical evidence/history of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease
You may not qualify if…
- Smoker
- Vegetarian
- Men and women who have fasting blood glucose concentration <100 or >125 mg/dL at screening visit
- Uncontrolled blood pressure ≥140 mmHg (systolic)/ ≥ 90 mmHg (diastolic)
- Over the counter supplements (e.g. fiber supplements, probiotics and/or prebiotics, antioxidants, anti-inflammation)
- Dietary supplements like (garlic, fish oil), glutamine supplements, grape seed extract, L-citrulline/arginine
- Cholesterol-lowering medications, anticoagulants, blood pressure-lowering medications,) and/or taking prescription medications that may interfere with study procedures or endpoints (e.g. gastrointestinal medications, antibiotics) within the last 30 days
- Have cancer other than non-melanoma skin cancer in previous 5 years
- Taking unstable dose of hormonal contraceptive and/or a stable dose less than 6 months
- Planning to become pregnant, pregnant and/or breast-feeding
- Excessive exerciser or a trained athlete
- Drink excessive amount of coffee/tea (> 5 cups per day)
- Donated blood within last 3 months
- Have allergies/intolerances to foods consumed in the study
- Currently eat > 2 servings of watermelons per day
- Actively losing weight/ trying to lose weight (unstable body weight fluctuations of > 11 lbs in 3 months)
- Addicted to drugs or alcohol
- Have significant psychiatric or neurological disturbances that may interfere with the ability to follow the study protocol
Where it is running
- Clinical Nutrition Research Center — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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