Study to Evaluate Suprachoroidally Administered CLS-AX in the Treatment of Neovascular Age-Related Macular Degeneration
Completed · Phase 2
Conditions studied: Neovascular Age-related Macular Degeneration
In brief
Phase 2b, randomized, double-masked, parallel-group, active-controlled, multicenter, 36-week study designed to assess the safety and efficacy of suprachoroidally administered CLS-AX 1.0 mg with a flexible dosing regimen in participants with neovascular age-related macular degeneration previously treated with intravitreal anti-vascular endothelial growth factor (VEGF) standard of care therapy. Only one eye will be chosen as the study eye.
Key facts
- Study ID
- NCT05891548
- Run by
- Clearside Biomedical, Inc.
- People needed
- 60
- Starts
- 2023-05-31
- Expected to finish
- 2024-08-20
- Last updated by the study team
- 2025-07-25
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Associated Retina Consultants — Phoenix, Arizona, United States
- Retinal Research Institute, LLC — Phoenix, Arizona, United States
- California Retina Consultants — Bakersfield, California, United States
- Retina Consultants of Orange County — Fullerton, California, United States
- Northern California Retina Vitreous Associates Medical Group, Inc — Mountain View, California, United States
- Retina Consultants San Diego — Poway, California, United States
- Retinal Consultants of Southern California — Redlands, California, United States
- Retinal Consultants Medical Group, Inc. — Sacramento, California, United States
- Retina Group of Florida — Fort Lauderdale, Florida, United States
- Florida Retina Consultants — Lakeland, Florida, United States
- Retina Specialty Institute — Pensacola, Florida, United States
- Retina Associates of Florida — Tampa, Florida, United States
- Southeast Retina Center — Augusta, Georgia, United States
- Georgia Retina, PC — Marietta, Georgia, United States
- Illinois Retina Associates — Oak Park, Illinois, United States
- Wolfe Eye Clinic — Des Moines, Iowa, United States
- Cumberland Valley Retina Consultants — Hagerstown, Maryland, United States
- Vitreo-Retinal Associates, PC — Worcester, Massachusetts, United States
- Sierra Eye Associates — Reno, Nevada, United States
- Envision Ocular LLC — Bloomfield, New Jersey, United States
- Western Carolina Retinal Associates P.A. — Asheville, North Carolina, United States
- Tennessee Retina PC — Nashville, Tennessee, United States
- Retina Research Institute of Texas — Abilene, Texas, United States
- Texas Retina Associates - Arlington — Arlington, Texas, United States
- Austin Retina — Austin, Texas, United States
Full record on ClinicalTrials.gov
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