Multi-parametric Imaging in Personalized Radiotherapy

Recruiting now

Conditions studied: Skull Base Chordoma

In brief

The study consists in the retrospective and prospective collection of imaging data (along with clinical information related to treatment) of skull-base chordoma patients treated with particle therapy, to derive imaging biomarkers which, integrated with advanced mathematical models, will allow predicting treatment outcome on a multi-scale basis.

Key facts

Study ID

NCT05888064

Run by

CNAO National Center of Oncological Hadrontherapy

People needed

35

Starts

2022-04-19

Expected to finish

2025-08-18

Last updated by the study team

2024-08-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with histologically confirmed diagnosis of chordoma of the skull base
• Particle therapy with curative intent
• Karnofsky Performance status greater than or equal to 60
• Patients with macroscopic disease detectable at pre-radiotherapy imaging
• Patients undergoing PT with standardized treatment procedures
• Patients who have signed the written informed consent for research

You may not qualify if…

• Metastatic disease
• Palliative treatment
• Other malignancies with disease-free interval < 5 years (excepting pre- cancerous lesions)
• Pregnancy
• Simultaneous CHT or Immunotherapy
• Extensive metal instrumentation/implants
• Patients with autoimmune diseases (ADs) -including collagen-vascular (CVD) and inflammatory bowel (IBD)

Where it is running

• CNAO — Pavia, Pv, Italy (enrolling)

Full record on ClinicalTrials.gov

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