Goal-directed LCVP Based on HP in Laparoscopic Hepatectomy
Recruiting now · Not applicable
Conditions studied: Hepatocellular Carcinoma
In brief
The goal of this clinical trial is to learn about goal-directed LCVP based on hypovolemic phlebotomy (HP) in laparoscopic hepatectomy. The main questions it aims to answer are: 1. The safety and feasibility of HP 2. To evaluate whether HP can reduce perioperative blood transfusion ratio Participants undergoing liver resection with HP was performed by the anesthesiologist. Blood was withdrawn approximately 30 min prior to the initiation of liver parenchymal transection from central venous. The aim was to maintain the CVP between 0 to 5 cmH2O. HP volume was 5-10 mL/kg of patient body weight, generally. Participants in control group undergoing liver resection without HP.
Key facts
- Study ID
- NCT05887661
- Run by
- The First Affiliated Hospital with Nanjing Medical University
- People needed
- 100
- Starts
- 2022-05-01
- Expected to finish
- 2026-05-01
- Last updated by the study team
- 2024-11-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Clinical diagnosis of Hepatocellular Carcinoma
- Preference for laparoscopic hepatectomy and patient agreement
You may not qualify if…
- Age <18 years
- Pregnancy
- Refusal of blood product transfusion
- Active cardiac conditions (unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease, history of congestive heart failure)
- History of significant cerebrovascular disease
- Restrictive or obstructive pulmonary disease
- Uncontrolled hypertension
- Renal dysfunction (glomerular filtration rate <60 mL/min),
- Hemoglobin <100 g/L
- Abnormal coagulation values (international normalized ratio >1.5 not on warfarin and/or platelet count <100 ×109/L)
- Evidence of hepatic metabolic disorder (bilirubin >35 mmol/L)
- Presence of active infection
- Preoperative autologous blood donation
- Patients were not allowed to receive erythropoietin at any time during the index hospitalization.
Where it is running
- The First Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
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