Sugammadex vs Neostigmine/Glycopyrrolate on Urinary Retention After Spine Surgery

Completed · Phase 4

Conditions studied: Spine Surgery, Reversal of Neuromuscular Blockade, Urinary Retention Postoperative

In brief

This is an active-comparator controlled study to evaluate the effect of sugammadex compared to neostigmine/glycopyrrolate for reversal of rocuronium on the incidence of urinary retention after subjects undergo elective ambulatory spine surgery.

Key facts

Study ID

NCT05887375

Run by

University of Missouri-Columbia

People needed

118

Starts

2023-08-03

Expected to finish

2026-01-15

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• ASA Physical Status I-III

You may not qualify if…

• Inability to obtain written informed consent
• Allergy to medications used in the protocol
• Known or suspected neuromuscular disorders
• Significant renal disease with a serum creatinine ≥ 2 mg/dL
• Significant liver disease
• A family history of malignant hyperthermia
• History of genitourinary surgery, cancer, or radiation within the last year
• Currently prescribed urological medications or diuretics
• BPH or symptoms of BPH (interrupted or weak urine stream or wake up to urinate more than two times per night)
• History or diagnosis of urinary incontinence or urinary retention
• History of PONV with use of scopolamine
• Use of Foley catheter pre- or intra- operatively
• Perioperative medications that influence micturition (e.g., diuretics or intraoperative anticholinergic medication use other than NMB reversal)

Where it is running

• University Hospital — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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