SCORE Emerging Adult Cannabis Use & Stress

Recruiting now · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Cannabis Use Disorder

In brief

The interface between cannabis use and stress is a particularly important focus for sex differences research in emerging adults. Given the dynamics at play in this critical stage when cannabis use is most prevalent, developmentally informed research is needed to guide tailored clinical interventions. This study will apply rigorous and innovative methods to elucidate sex differences in the nexus of cannabis use and stress among emerging adults with cannabis use disorder to guide the development of tailored treatments.

Key facts

Study ID

NCT05885542

Run by

Medical University of South Carolina

People needed

148

Starts

2023-11-01

Expected to finish

2028-07-31

Last updated by the study team

2025-11-05

Who can join

Age: 18 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments
• Meet DSM-5 criteria for CUD and report using cannabis at least five times weekly over the past month. While individuals may also meet criteria for other mild substance use disorders, they must identify cannabis as their primary substance
• Age 18-25
• BMI between 18-30 (to decrease variability in CBD response and in endocannabinoid system measures)
• AST, ALT, and total bilirubin within the laboratory reference range of normal
• Consent to alcohol abstinence for 12 hours prior to study visits, three days of cannabis abstinence as part of study procedures, and abstinence from all substances aside from cannabis, alcohol, and nicotine for the duration of the study
• Sexually active females of childbearing potential must agree to utilize an effective means of birth control.
• Consent to random assignment to CBD versus placebo

You may not qualify if…

• Females who are pregnant, nursing, or planning to become pregnant during the study.
• Current severe substance use disorder other than cannabis
• Current medications or supplements with clinically significant interactions with cannabidiol (per Lexicomp, this list includes Blasting, Doxorubicin, Mavacamten, Pazopanib, Sirolimus, Topotecan, Vincristine, Afatinib, Berotraslstat, Cilostazol, Citalopram, Colchicine, Digoxin, Lefamulin, Relugolix, Relugolix+Estradiol+Norethindrone, Rimegepant, Tizanidine, Ubrogepant, and Venetoclax in the categories of "avoid combination" or "consider therapy modification")
• Current unstable psychiatric or medical disorder that would interfere with safety, compromise data integrity, or preclude reliable participation
• History of hypersensitivity to CBD, sesame, or sesame products
• Inability to comply with study procedures

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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