Screening Effect of Dual-energy CT Combined With Nasopharyngeal Endoscopy for Screening Nasopharyngeal Carcinoma

Recruiting now

Conditions studied: Nasopharyngeal Carcinoma

In brief

All participants will be tested for EBV-related biomarkers, including EBNA1-IgA, VCA-IgA, and BNLF2b total antibody (P85-Ab), and participants with high serologic risk will be selected based on serologic test results, and dual-energy CT will be performed first for high-risk screening subjects, and dual-energy CT will be performed first for the high-risk group to record dual-energy CT examinations of those suspected of nasopharyngeal carcinoma, and then endoscopy was performed on the high-risk group to record those suspected of nasopharyngeal carcinoma under endoscopy, and finally biopsies were taken for positive lesion sites indicated by dual-energy CT and suspicious lesion sites found by endoscopy to clarify the diagnosis.

Key facts

Study ID

NCT05884983

Run by

Zhongshan People's Hospital, Guangdong, China

People needed

12000

Starts

2023-02-01

Expected to finish

2026-12-31

Last updated by the study team

2025-08-15

Who can join

Age: 30 and older, up to 69. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subject residents in Zhongshan City
• Subject has no medical record of nasopharyngeal carcinoma
• Subject is able to comprehend, sign, and date the written informed consent document to participate in the study
• Subject has psychical condition and well consciousness, and also accept and cooperate with the follow-up of this study

You may not qualify if…

• Subject has heavy cardiovascular, liver or kidney disease
• Subject has contraindications to nasopharyngeal endoscopy
• Subject has contrast media allergy

Where it is running

• Zhongshan People's Hospital — Zhongshan, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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