A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease

Completed · Phase 3 · Has a placebo group

Conditions studied: Obesity, Cardiovascular Diseases

In brief

The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks.

Key facts

Study ID

NCT05882045

Run by

Eli Lilly and Company

People needed

1946

Starts

2023-05-30

Expected to finish

2026-05-14

Last updated by the study team

2026-07-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a body mass index (BMI) ≥35.0 kilogram/square meter (kg/m²).
• Have established cardiovascular (CV) disease with at least 1 of the following:
• prior myocardial infarction
• prior ischemic or hemorrhagic stroke, or
• symptomatic peripheral arterial disease
• Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight.

You may not qualify if…

• Have had acute myocardial infarction, stroke, coronary revascularization, hospitalization for unstable angina, or hospitalization due to congestive heart failure within 90 days prior to screening.
• Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening.
• Have a prior or planned surgical treatment of obesity.
• Have a change in body weight greater than 5 kg (11 pounds) within 90 days prior to screening.
• Have Type 1 diabetes.
• Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
• Have had pancreatitis.

Where it is running

• Valley Clinical Trials, Inc. — Covina, California, United States
• Neuro-Pain Medical Center — Fresno, California, United States
• Valley Research — Fresno, California, United States
• Collaborative Neuroscience Research, LLC — Los Alamitos, California, United States
• Velocity Clinical Research, Westlake — Los Angeles, California, United States
• Valley Clinical Trials, Inc. — Northridge, California, United States
• Velocity Clinical Research, Panorama City — Van Nuys, California, United States
• Chase Medical Research, LLC — Waterbury, Connecticut, United States
• Indago Research & Health Center, Inc — Hialeah, Florida, United States
• Clinical Neuroscience Solutions, Inc. dba CNS Healthcare — Jacksonville, Florida, United States
• Clinical Neuroscience Solutions, Inc. — Orlando, Florida, United States
• Charter Research - Winter Park — Orlando, Florida, United States
• Progressive Medical Research — Port Orange, Florida, United States
• Pacific Diabetes & Endocrine Center — Honolulu, Hawaii, United States
• Elite Clinical Trials — Blackfoot, Idaho, United States
• Humphreys Diabetes Center — Boise, Idaho, United States
• Northwestern University — Chicago, Illinois, United States
• Great Lakes Clinical Trials - Gurnee — Gurnee, Illinois, United States
• Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative — Springfield, Illinois, United States
• Brengle Family Medicine — Indianapolis, Indiana, United States
• Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa, United States
• Cotton O'Neil Diabetes & Endocrinology — Topeka, Kansas, United States
• MedVadis Research Corporation — Waltham, Massachusetts, United States
• StudyMetrix Research — City of Saint Peters, Missouri, United States
• Central Phoenix Medical Clinic — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.