Prevalence, Incidence and Risk Signature of Chronic Kidney Disease in Sub-Saharan Africa

Recruiting now

Conditions studied: Chronic Kidney Diseases, Type 2 Diabetes Mellitus, Arterial Hypertension, Obesity, Cardiovascular Diseases, HIV Infections, Anemia, Underweight, Infections, Albuminuria, Dyslipidemias

In brief

Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. The prevalence of CKD is increasing worldwide and is assumed to also dramatically increase in Sub-Saharan Africa (SSA). Key shortcomings of available data on CKD in SSA are as follows: (i) Available data are based on single measurements and, therefore, cannot distinguish between harmless transient deterioration in kidney function and chronic kidney damage; (ii) Accurate information regarding renal protein loss, an important and early marker of kidney disease, is lacking; (iii) Cardiovascular risk factors for CKD, such as obesity, hypertension and diabetes, are often not searched for. Likewise non-classic potential risk factors, such as endemic infectious diseases, socioeconomic status and lifestyle have not been consistently recorded; (iv) Information to interrogate linked interaction over time between risk factors and development of CKD is unavailable. With this project, situated in a region representative of semi-rural SSA, we aim to fill this knowledge gap and (i) establish guideline conform prevalence data of CKD and its major cardiovascular risk factors, as well as (ii) prospectively define the incidence of cardiovascular- and non-classic risk factors of CKD. The data from (i) and (ii) is used to develop predictive models. A prospective cohort of 1200 individuals in a primary care facility will serve as study population. The population is representing a society in transition from rural to more urban lifestyle. In the pilot study, participants will be followed for one years and undergo the clinical and biomedical testing required to capture CKD and its classic and non-classic risk factors over time.

Key facts

Study ID: NCT05881447
Run by: Swiss Tropical & Public Health Institute
People needed: 1200
Starts: 2023-06-21
Expected to finish: 2026-12-31
Last updated by the study team: 2026-04-29

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

all adult patients (≥18 years) attending the outpatients department of the Bagamoyo district hospital (BDH) or the associated Fukayosi and Yombo dispensary

You may not qualify if…

<18 years of age
not living in the BDH catchment area
not of African decent
not willing to come back for follow-up visits

Where it is running

Bagamoyo District Hospital — Bagamoyo, Coast Region, Tanzania (enrolling)

Full record on ClinicalTrials.gov

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