Perinatal Outcomes Following Change in Clinical Criteria in for Treatment of Maternal Hypertension
Completed
Conditions studied: Maternal Hypertension
In brief
The purpose of this study is observe outcomes before and after a change in clinical practice in the threshold for management of severe hypertension in pregnancy and the post-partum period. Outcomes will be observed for 10 months under the current (traditional) clinical blood pressure threshold for acute treatment of hypertension, which is \>= 160 millimeters of mercury (mmHg) systolic blood pressure (SBP). This will be followed by one month of education about rationale for the new SBP threshold of \>= 180 mmHg and change of clinical guidelines. Then, there will be 10 months of observation after adopting the updated clinical threshold for acute antihypertensive treatment (\>= 180 SBP).
Key facts
- Study ID
- NCT05881252
- Run by
- The University of Texas Health Science Center, Houston
- People needed
- 1003
- Starts
- 2023-05-11
- Expected to finish
- 2024-04-04
- Last updated by the study team
- 2025-07-28
Who can join
Age: any. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- any individual > 20 weeks' gestation in triage or admitted at Children's Memorial Hermann Hospital (CMHH) and with blood pressure with >= 160/110 mmHg
You may not qualify if…
- Active seizure, stroke, Congestive Heart Failure (CHF)/pulmonary edema, acute kidney injury (AKI), or myocardial infarction (MI)
- A history of stroke, CHF, chronic kidney disease (CKD), MI
- Have Hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome or thrombocytopenia (platelets < 100×10\^9/L)
- Persistent neurologic symptoms including headache >8/10 one hour after analgesic or blurry vision/loss of vision
Where it is running
- UT Houston — Houston, Texas, United States
Full record on ClinicalTrials.gov
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