A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
Recruiting now · Phase 1
Conditions studied: Non-small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Colorectal Carcinoma, Pancreatic Adenocarcinoma, Breast Cancer, Other Solid Tumors, Ovarian Cancer, Myeloid Neoplasms (AML/MDS)
In brief
Phase I Study of NT-175, an autologous T cell therapy product genetically engineered to express an HLA-A\*02:01-restricted T cell receptor (TCR), targeting TP53 R175H mutant malignancies
Key facts
- Study ID
- NCT05877599
- Run by
- AstraZeneca
- People needed
- 45
- Starts
- 2023-07-12
- Expected to finish
- 2029-07-31
- Last updated by the study team
- 2026-08-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Research Site — Milwaukee, Wisconsin, United States (enrolling)
- Research Site — Duarte, California, United States (enrolling)
- Research Site — Newport Beach, California, United States (enrolling)
- Research Site — Santa Monica, California, United States (enrolling)
- Research Site — Jacksonville, Florida, United States (enrolling)
- Research Site — Nashville, Tennessee, United States (enrolling)
- Research Site — Houston, Texas, United States (enrolling)
- Research Site — Round Rock, Texas, United States (enrolling)
- Research Site — Gilbert, Arizona, United States (enrolling)
- Research Site — Boston, Massachusetts, United States (enrolling)
- Research Site — New Brunswick, New Jersey, United States (enrolling)
- Research Site — New York, New York, United States (enrolling)
- Research Site — Portland, Oregon, United States (enrolling)
- Research Site — Pittsburgh, Pennsylvania, United States (enrolling)
- Research Site — Miami, Florida, United States
- Research Site — Tampa, Florida, United States
- Research Site — Winston-Salem, North Carolina, United States
- Research Site — Charlotte, North Carolina, United States
Full record on ClinicalTrials.gov
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