A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Recruiting now · Not applicable
Conditions studied: Mild Cognitive Impairment, Alzheimer Disease, Cognitive Impairment, Cognitive Decline, Memory Loss, Memory Impairment
In brief
The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes; * identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and * examines the mechanisms of aerobic exercise's action on memory in older adults with early AD. Participants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.
Key facts
- Study ID
- NCT05877196
- Run by
- Arizona State University
- People needed
- 216
- Starts
- 2023-06-22
- Expected to finish
- 2028-06-30
- Last updated by the study team
- 2026-05-05
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participants:
- Clinical diagnosis of MCI or probable and possible mild AD dementia according to 2011 Alzheimer's association-NIA criteria.
- Community-dwelling, e.g., homes and assisted living
- Age 65 years and older
- Medical clearance from PCP or cardiovascular provider
- Have a qualified study partner
- Agree to the blood draws
- Verified MRI safety
- Study Partner:
- Age 18 or older
- Contact with participant ≥ 2 times per week for ≥ 6 months
- Know the participant's memory status and ability to perform activities of daily living
- Consent to participant
You may not qualify if…
- Participants
- Resting HR ≤ 50 or ≥ 100 beats/min after 5-minutes of quiet resting
- American College of Sports Medicine contraindications to exercise
- New, unevaluated symptoms or diseases a healthcare provider has not evaluated
- Abnormal cardiac condition uncovered during VO2peak testing
- Enrollment in another intervention that aims at improving cognition
- Moderate to strenuous exercise ≥150 minutes a week in the previous 6 months
- ≥ 2 anti-depression medications, or poorly managed or unstable depression
- Poorly managed or unstable anxiety
- Study partners:
- none
Where it is running
- Arizona State University — Phoenix, Arizona, United States (enrolling)
Full record on ClinicalTrials.gov
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