Ovarian Tissue Cryopreservation for Fertility Preservation

Recruiting now

Conditions studied: Cancer, Autoimmune Diseases

In brief

The goal of this observational study is to learn about fertility preservation for pre-pubertal, peri-pubertal, and adult participants that are unable to pursue clinical standard of care fertility preservation such as egg (oocyte) and embryo cryopreservation. In addition, this study will provide research tissue for the following Specific Aims: 1. To optimize techniques for cryopreservation of ovarian tissues from patients at significant risk for infertility. 2. To investigate factors affecting successful maturation ovarian tissue. Participants will undergo a surgical procedure to remove an ovary (oophorectomy) to preserve their gonadal tissue for fertility preservation.

Key facts

Study ID

NCT05875155

Run by

University of Pittsburgh

People needed

500

Starts

2011-01-13

Expected to finish

2031-01-01

Last updated by the study team

2026-03-04

Who can join

Age: any, up to 39. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Be female age less than 40 years old.
• Unable or unwilling to make use of oocyte or embryo banking alone.
• Be scheduled to undergo surgery, chemotherapy, drug treatment and/or radiation for the treatment or prevention of a medical condition or malignancy with risk of causing permanent and complete loss of subsequent ovarian function.
• Or, have a medical condition or malignancy that requires removal of all or part of one or both ovaries.
• Or, Have newly diagnosed or recurrent disease. Those who were not enrolled at the time of initial diagnosis (i.e., patients with recurrent disease) are eligible if they have not previously received therapy that is viewed as likely to result in complete and permanent loss of ovarian function.
• Have two ovaries if undergoing elective removal of an ovary for fertility preservation only.

You may not qualify if…

• Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.
• Diagnosed with an underlying medical condition that significantly increases their risk of complications from anesthesia and surgery.

Where it is running

• Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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