Pegylated Interferon α-2b in Combination With Ruxolitinib for Treating Hydroxyurea-resistant/Intolerant PV

Recruiting now · Phase 2

Conditions studied: Polycythemia Vera

In brief

Study purpose: To compare the efficacy and safety of pegylated interferon α-2b in combination with ruxolitinib versus pegylated interferon α-2b alone for treating hydroxyurea-resistant or hydroxyurea-intolerant polycythemia vera.

Key facts

Study ID

NCT05870475

Run by

Institute of Hematology & Blood Diseases Hospital, China

People needed

94

Starts

2023-06-30

Expected to finish

2028-05-31

Last updated by the study team

2024-07-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥18 years old.
• Male or Female.
• Meets the diagnostic criteria for Polycythemia Vera according to WHO-2022.
• Resistant or intolerant to hydroxyurea (based on the 2013 European LeukemiaNet criteria).
• Have not previously received interferon preparations or ruxolitinib treatment, or the washout period between the last use of interferon preparations or ruxolitinib and the first use of the study drug should not be less than 4 weeks.
• Patients with indications for cytoreductive therapy.
• During screening, female hemoglobin (HGB) ≥10g/dL, male hemoglobin (HGB) ≥11g/dL; neutrophil count ≥1.5×109/L; platelet count ≥100×109/L.
• Voluntary written informed consent.

You may not qualify if…

• Symptomatic splenomegaly;
• Contraindications to interferon or ruxolitinib therapy;
• Severe or significant comorbidities that may affect the participant's ability to participate in the study, as determined by the investigator;
• History of major organ transplantation;
• Pregnant or breastfeeding women;
• History or current diagnosis of autoimmune thyroid disease (patients with controlled hypothyroidism on oral thyroid hormone replacement therapy may be included);
• Documented evidence of any other autoimmune disease (such as active hepatitis, systemic lupus erythematosus, antiphospholipid antibody syndrome, or autoimmune arthritis);
• Clinically significant bacterial, fungal, mycobacterial, parasitic, or viral infection such as active hepatitis or HIV infection (patients with acute bacterial infections requiring antibiotic treatment should be deferred from screening/enrollment until completion of antibiotic treatment);
• Evidence of severe retinopathy or clinically significant ophthalmologic disease (due to diabetes or hypertension);
• Current clinically significant depression or history of depression, or any suicidal attempt or tendency during screening;
• Active bleeding or thrombotic complications;
• History of any malignant tumor within the past 5 years (except for stage 0 chronic lymphocytic leukemia [CLL], cured basal cell carcinoma, squamous cell carcinoma, and superficial melanoma);
• History of alcohol or substance abuse within the past year;
• Presence of blasts in the peripheral blood within the past 3 months;
• Use of any investigational drug or participation in any other clinical trial within 4 weeks prior to the first dose of the study drug, or failure to recover from any effects of previously administered study drugs;
• The investigator deems the presence of any concurrent condition that may jeopardize the safety of the participant or the compliance to the protocol.

Where it is running

• Institute of Hematology & Blood Diseases Hospital — Tianjin, China (enrolling)

Full record on ClinicalTrials.gov

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