Implantation of iodine125-Seeds Combined With Chemotherapy in the Treatment of Metastatic Pancreatic Carcinoma

Recruiting now · Not applicable

Conditions studied: Metastatic Pancreatic Cancer

In brief

The goal of this clinical trial is to evaluate the clinical efficacy and safety of endoscopic ultrasonography (EUS)-guided radioactive iodine 125 seeds in combination with AG regimen chemotherapy for the treatment of metastatic pancreatic cancer. The main questions it aims to answer are: * whether the combination of minimally invasive endoscopy-guided local radiation therapy with chemotherapy may improve overall survival * the adverse events of the combination therapy Participants will receive the implantation of radioactive seeds under EUS guide. 48h after implantation, chemotherapy with Gem/nab-P given on days 1 and 8 of each 21-day cycle will be conducted. Researchers will compare the I125+AG group with the group that takes AG chemotherapy alone to see if the overall survival can be improved.

Key facts

Study ID

NCT05869474

Run by

Changhai Hospital

People needed

206

Starts

2023-08-01

Expected to finish

2027-12-01

Last updated by the study team

2023-08-04

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• (Before the trial, subjects must meet all of the requirements listed below in order to be enrolled)
• 18 to 80 years old;
• Stage IV pancreatic ductal adenocarcinoma with distant metastases confirmed by clinical, imaging, and pathology, and the primary and metastatic mass can be measured on imaging.
• No treatment history of chemotherapy, radiotherapy, or surgery
• Expected survival > 6 months
• ECGO score of 0-2
• Eligible for chemotherapy (white blood cell > 3.5×109/L, neutrophil value > 1.5×109/L, hemoglobin > 80g/L, platelets > 100×109/L, albumin > 25g/L, alanine aminotransferase or aspartate aminotransferase ≤ 3 times the upper limit of normal and total bilirubin level ≤ 34.2umol/L, creatinine < 176.8 umol/L, normal ECG)
• Signed written informed consent;

You may not qualify if…

• Contraindication of EUS-guide procedure or technical infeasibility (e.g.,coagulation disorder, anatomical changes, large vessels along the puncture path)
• Pregnant or breastfeeding
• Presence of brain metastases
• Presence of deep vein thrombosis or pulmonary embolism
• Presence of HIV, HBV, HCV infection or other uncontrollable active infection
• Hypersensitivity to chemotherapy drugs
• History of other malignancies within 5 years
• Peripheral neuropathy or interstitial lung disease within 5 years
• Patient is enrolled in any other clinical protocol or investigational trial.

Where it is running

• Changhai Hospital — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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