Study of AVZO-021 in Patients With Advanced Solid Tumors
Recruiting now · Phase 1/Phase 2
Conditions studied: Advanced Solid Tumor, HR+/HER2- Breast Cancer, HR+, HER2-, Advanced Breast Cancer, CCNE1 Amplification, Epithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer, Endometrial Cancer, TNBC - Triple-Negative Breast Cancer
In brief
This study, the first clinical trial of AVZO-021, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and anti-tumor effects of AVZO-021 in patients with advanced solid tumors. AVZO-021 is an oral medication that inhibits cyclin-dependent kinase 2 (CDK 2).
Key facts
- Study ID
- NCT05867251
- Run by
- Avenzo Therapeutics, Inc.
- People needed
- 430
- Starts
- 2023-08-30
- Expected to finish
- 2030-01-31
- Last updated by the study team
- 2025-11-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Yale Cancer Center — New Haven, Connecticut, United States (enrolling)
- Florida Cancer Specialists — Sarasota, Florida, United States (enrolling)
- Moffitt Cancer Center — Tampa, Florida, United States (enrolling)
- Perlmutter Cancer Center at NYU Langone Hospital - Long Island — Mineola, New York, United States (enrolling)
- NYU Langone Medical Center (Tisch Hospital) — New York, New York, United States (enrolling)
- University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States (enrolling)
- Oklahoma University — Oklahoma City, Oklahoma, United States (enrolling)
- Providence Cancer Institute — Portland, Oregon, United States (enrolling)
- Sidney Kimmel Cancer Center (SKCC) at Jefferson Health — Philadelphia, Pennsylvania, United States (enrolling)
- Texas Oncology - DFW — Dallas, Texas, United States (enrolling)
- NEXT Virginia — Fairfax, Virginia, United States (enrolling)
- Macquarie University Hospital — Macquarie University, New South Wales, Australia (enrolling)
- Cancer Care Wollongong — Wollongong, New South Wales, Australia (enrolling)
Full record on ClinicalTrials.gov
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