Vascular MRI Evaluation in Giant Cell Arteritis (VEGA)

Recruiting now

Conditions studied: Giant Cell Arteritis

In brief

The research study is being conducted to determine the utility of magnetic resonance imaging (MRI) in identifying inflammation of arteries supplying blood to the head, brain, and eyes. The target population includes patient with suspected giant cell arteritis (GCA; temporal arteritis).

Key facts

Study ID

NCT05865054

Run by

University of Pennsylvania

People needed

400

Starts

2020-07-29

Expected to finish

2033-07-01

Last updated by the study team

2025-09-19

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 50 years or older
• First presentation of suspected GCA
• New or worsening cranial manifestations within 4 weeks of enrollment concerning for active GCA
• Elevated CRP greater than 1.0 mg/dl
• Plan to undergo temporal artery biopsy or ultrasound for diagnosis

You may not qualify if…

• Contra-indication to receiving MRI including:
• Implanted medical devices, pacemaker, and metallic foreign fragments inside body/orbits Known gadolinium allergy Women who are pregnant or nursing
• Absence of cranial symptoms related to GCA (e.g., only large vessel GCA)

Where it is running

• Mayo Building and Gonda Building — Rochester, Minnesota, United States (enrolling)
• 3400 Civic Center Blvd — Philadelphia, Pennsylvania, United States (enrolling)
• St. Joseph's Healthcare Hamilton — Hamilton, Ontario, Canada
• University Hospital Wuerzburg — Würzburg, Würzburg, Germany

Full record on ClinicalTrials.gov

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