Brain Blood Flow Responses During Exercise

Running, not enrolling · Not applicable

Conditions studied: Cerebrovascular Circulation, Magnetic Resonance Imaging

In brief

Brain blood flow will be measured during exercise using magnetic resonance imaging.

Key facts

Study ID

NCT05864950

Run by

University of Wisconsin, Madison

People needed

80

Starts

2024-03-06

Expected to finish

2027-05-31

Last updated by the study team

2026-07-13

Who can join

Age: 55 and older, up to 69. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy men or women between the ages of 55-69 years
• Demonstrate an exercise history of engaging in aerobic physical activity at least 3 times per week for a minimum of 30 continuous minutes
• Have experience using cardiovascular exercise equipment (e.g., treadmill, elliptical, upright or recumbent bicycle, stair-stepper)

You may not qualify if…

• Outside of specified age range
• Do not have experience using cardiovascular exercise equipment
• Do not meet the physical activity criteria
• Present with a history or evidence of hepatic, renal, hematological disease, cardiovascular disease including uncontrolled hypertension, peripheral vascular disease, stroke/neurovascular disease, and diabetes
• have a body mass index ≥35 kg/m2
• are ≥ 71 inches (180 cm) in height
• have any contraindications to MRI
• currently use or have a history of use of tobacco or illegal substances
• have current and/or a history of depression or other mood related disorders (those with mild depression and/or anxiety that is controlled with medication and/or therapy will not be excluded)
• vulnerable populations (e.g., pregnant women, prisoners, individuals lacking capacity to consent)
• if the desired moderate/vigorous exercise intensity corresponds to > 350 watts on the stepper device

Where it is running

• University of Wisconsin-Madison — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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