PAI-1, tPA, TFPI and HEECs in Uterine Hemostasis

Recruiting now · Phase 1/Phase 2

Conditions studied: Menstrual Bleeding, Heavy

In brief

The purpose of the study is to learn more about the role of blood clotting factor proteins and cells in menstrual (period) bleeding. The investigators are hoping to identify differences in these proteins and cells in the menstrual blood of individuals with heavy periods compared to menstruating individuals who do not have heavy periods.

Key facts

Study ID

NCT05862805

Run by

Oregon Health and Science University

People needed

70

Starts

2023-07-12

Expected to finish

2026-07-01

Last updated by the study team

2024-08-19

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Regularly menstruating participants between 18-45 years of age

You may not qualify if…

• Pregnancy within 3 months of enrollment
• Lactating at the time of enrollment
• Hormonal contraceptive use or use of the copper intrauterine device (IUD)
• Antifibrinolytic use
• Inherited or acquired bleeding disorder or anticoagulant use
• Known structural cause of HMB
• Inability to complete PBACs
• Unwilling to refrain from sexual intercourse for the two weeks prior to endometrial biopsy

Where it is running

• OHSU — Portland, Oregon, United States (enrolling)

Full record on ClinicalTrials.gov

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