Two Cycles VS Three Cycles Induction Chemotherapy in T1-4N2-3 Locally Advanced Nasopharyngeal Carcinoma

Recruiting now · Phase 3

Conditions studied: Locally Advanced Nasopharyngeal Carcinoma

In brief

This trial is a multi-center phase III clinical trial. The purpose of this trial is to explore whether 2 cycles induction chemotherapy combined with concurrent chemoradiotherapy is not inferior to 3 cycles induction chemotherapy combined with concurrent chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma.

Key facts

Study ID

NCT05860868

Run by

First Affiliated Hospital, Sun Yat-Sen University

People needed

474

Starts

2023-05-01

Expected to finish

2030-05-01

Last updated by the study team

2023-05-16

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-65 years old;
• Pathologically confirmed non-keratinizing nasopharyngeal carcinoma;
• Stage T3-4N0-1 (according to the UICC/AJCC 8th);
• No distant metastasis;
• Have not received anti-cancer treatment in the past;
• ECOG (Eastern Cooperative Oncology Group of the United States): 0-1;
• Adequate hematologic, hepatic and renal function.

You may not qualify if…

• The purpose of treatment is palliative;
• Diagnosed with other malignant tumors at the same time;
• Malignant tumor history;
• Pregnancy or breastfeeding, or expect to become pregnant during the clinical trial period;
• Combined serious illness.

Where it is running

• First Affiliated Hospital, Sun Yat-Sen University — Guangzhou, Other (Non U.s.), China (enrolling)

Full record on ClinicalTrials.gov

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