The Impact of Beef on Muscle Fatigue in Older Adults
Completed · Not applicable
Conditions studied: Muscle Weakness, Muscle; Fatigue, Heart, Older Adults
In brief
The goal of this controlled-feeding cross-over diet intervention is to compare a beef diet to a vegetarian diet on muscle fatigue in older adults. The aims are: AIM 1: To test the hypothesis that muscle fatigue is attenuated in older adults consuming beef compared to older adults consuming a plant-based diet. AIM2: To test the hypothesis that daily beef consumption improves biochemical indicators related to muscle fatigue. Participants will be randomized to consume either a beef-based diet or vegetarian diet under controlled-feeding conditions for 8 weeks. After a 2-week washout period, participants will cross-over to consume either the beef diet or vegetarian diet for 8 weeks. Body composition and functional muscle outcomes will be measured during each 8-week feeding period. Blood samples will also be collected.
Key facts
- Study ID
- NCT05860088
- Run by
- Indiana University
- People needed
- 24
- Starts
- 2023-07-10
- Expected to finish
- 2025-11-21
- Last updated by the study team
- 2026-05-01
Who can join
Age: 60 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ages 60-85 years
- Ability to eat study diet meals for a total of 16 weeks
- Ability to perform sit-to-stand chair and 6-minute walking tests based on results from PAR-Q questionnaire
- Ability to provide fasted blood samples
- Access to transportation
- Willing to abstain from alcohol consumption and/or use illicit drug use for each 8-week intervention period
- Ability to consent to participating in this study
- English-speaking
- Body mass index between 18.5 (normal) and 39.9 (obese) kg/m2
- Minimum total body weight of 110 pounds
- Non-anemia hemoglobin values: Females - >12.0 grams/dL; Men - >13.0 grams/dL
- Able to ambulate without assistance
- Physician's clearance for study participation (required prior to baseline testing)
You may not qualify if…
- Inability or refusal to sign the informed consent
- Significant orthopedic limitations or other contraindications to exercise
- Inability or refusal to perform muscle fatigue tests
- Has dietary restrictions that prevent to consumption of beef, soy and/or wheat
- Has liver or kidney complications
- Live or work >25 miles from Bloomington study site or does not have transportation to the study site
- Anticipate elective surgery during the study period
- Diagnosis of progressive neurological disorders, musculoskeletal disorders, osteoarthritis, rheumatoid arthritis
- Fracture or serious injury in the last 6 months
- Stroke, revascularization, deep vein thrombosis, or pulmonary embolism in the past 12 months
- Severe cardiovascular disease, uncontrolled systemic hypertension, chronic pulmonary disease
- Plan to move residence or travel out of the local area during the study period
- Current use of anti-coagulants (e.g. Coumadin or Warfarin)
- Current use of prescription medications that affect heart rate or blood vessel dilation
- Psychological or social characteristics that would interfere with their ability to fully participate in the study
Where it is running
- Indiana University Bloomington — Bloomington, Indiana, United States
Full record on ClinicalTrials.gov
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