Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements

Recruiting now

Conditions studied: Anti-Müllerian Hormone, Polycystic Ovarian Syndrome, Premature Ovarian Insufficiency, Fertility Issues

In brief

This study aims to assess the association of Anti-Müllerian hormone (AMH) with polycystic ovarian syndrome, premature ovarian insufficiency and fertility. The main objectives include the following: 1. To study the level of serum AMH in women with PCOS and to evaluate the utility of serum AMH in the diagnosis of PCOS. 2. To evaluate the level of serum AMH in women with POI and to evaluate the utility of serum AMH in the management of POI. 3. To evaluate the associations of basal AMH level with FSH level and AFC respectively for women undergoing ART treatment. 4. To determine the optimal regimen of gonadotropin for ovarian stimulation for women undergoing ART treatment. 5. To evaluate the predictive value of serum AMH in reproductive outcomes including oocyte quality, embryo quality, pregnancy loss, clinical pregnancy and live birth rate in women undergoing ART treatment.

Key facts

Study ID

NCT05858307

Run by

Chinese University of Hong Kong

People needed

300

Starts

2022-06-22

Expected to finish

2026-12-31

Last updated by the study team

2025-03-27

Who can join

Age: 10 and older, up to 44. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women attending the Paediatric and Adolescent Gynaecological Clinic and Gynaecological Endocrine Clinic of in the Department of Obstetrics and Gynaecology at the Prince of Wales Hospital for the management of PCOS and POI
• Women attending the Assisted Reproductive Technology (ART) Unit of The Chinese University of Hong Kong for ART treatment

You may not qualify if…

• Women with age <10 or ≥45
• Current or past diseases affecting gonadotropin, sex steroid secretion, clearance and excretion

Where it is running

• The Chinese University of Hong Kong — Hong Kong, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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