Low-Intensity Focused Ultrasound for Cocaine Use Disorder
Completed · Not applicable · Has a placebo group
Conditions studied: Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
In brief
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings. Data analysis will serve to show if 1) LIFU is safe and effective and to 2) examine the effects of LIFU on dAI BOLD activity and craving in response to cocaine cue-exposure. The study will screen 60 individuals with Cocaine Use Disorder (CUD) to arrive at 30 enrolled subjects, based on a 2:1 screen/randomization ratio.
Key facts
- Study ID
- NCT05857852
- Run by
- University of Virginia
- People needed
- 25
- Starts
- 2023-03-24
- Expected to finish
- 2025-08-31
- Last updated by the study team
- 2026-05-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ages 18 years and older with a history of cocaine use disorder
- Have a current (past 6 months) DSM-5 diagnosis of cocaine use disorder (4 or more symptoms) assessed using the MINI neuropsychiatric interview
- Have a blood alcohol content by breathalyzer, equal to 0.000 when informed consent document is signed
- Ability to abstain from cocaine use at key points during study
- Willingness and ability to comply with scheduled visits and study procedures
- Ability to lie down for extended periods of time for imaging tests
- Will have reliable transportation throughout study
- Will have a stable residence during the 2 weeks prior to randomization and not be at risk of losing housing in next 2 months
- Must meet criteria to have magnetic resonance imaging (MRI)
You may not qualify if…
- Please contact PI or Study Coordinator for more details.
Where it is running
- UVA Center for Leading Edge Addiction Research — Charlottesville, Virginia, United States
Full record on ClinicalTrials.gov
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