Exercise Response in Humans With Obesity

Recruiting now

Conditions studied: Obese

In brief

This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.

Key facts

Study ID

NCT05857150

Run by

Mayo Clinic

People needed

120

Starts

2023-09-22

Expected to finish

2029-07-01

Last updated by the study team

2025-08-29

Who can join

Age: 20 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Obese men and women ≥ 20 and ≤ 45 years of age.

You may not qualify if…

• Diabetes or fasting plasma glucose >126 mg/dL
• Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl)
• Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
• Renal failure (serum creatinine > 1.5mg/dl)
• Chronic active liver disease defined as aspartate aminotransferase (AST)>144 IU/L or alanine transaminase (ALT) >165 IU/L)
• Oral warfarin group medications or history of blood clotting disorders.
• Smoking
• Pregnancy or breastfeeding
• Alcohol consumption greater than 2 glasses/day or other substance abuse
• Untreated or uncontrolled hypothyroidism
• Debilitating chronic disease (at the discretion of the investigators)

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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