Psychosis TMS Study

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Psychosis

In brief

The main goal of this study is to investigate the neural mechanisms of working memory function in patients with early psychosis using Transcranial Magnetic Stimulation (TMS) in conjunction with functional MRI. TMS is a noninvasive method used to modulate brain activity via changing magnetic fields applied over the surface of the scalp.

Key facts

Study ID

NCT05857137

Run by

Massachusetts General Hospital

People needed

20

Starts

2023-04-04

Expected to finish

2026-07-30

Last updated by the study team

2026-02-10

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of psychosis, psychosis not otherwise specified, schizophrenia, schizoaffective disorder, delusional disorder, bipolar disorder with psychosis, and schizophreniform disorder within first ten years of onset of psychotic symptoms.
• Ability to provide informed consent

You may not qualify if…

• TMS incompatibility including metallic implants in head and neck, cardiac pacemakers, history of seizures, pregnancy.
• MRI-incompatibility including implanted aneurism clips, cardiac pacemakers, metal implants, intrauterine devices, tattoos containing metal ink, pregnancy, and claustrophobia
• Severe substance abuse within 3 months (nicotine allowed)
• Unstable medical or neurologic illness that would preclude participation in study procedures

Where it is running

• Martinos Center for Biomedical Imaging — Charlestown, Massachusetts, United States

Full record on ClinicalTrials.gov

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