Creatine Supplementation for Improved Voice Performance in the Elderly

Paused · Not applicable · Has a placebo group

Conditions studied: Presbyphonia

In brief

The primary objective of this study is to determine if creatine supplementation improves acoustic, auditory perceptual, physiologic, and patient-reported outcome measures in patients over 65 years of age. In the study, 20 participants will be enrolled and randomly assigned to receive either creatine or placebo.

Key facts

Study ID

NCT05856916

Run by

NYU Langone Health

People needed

20

Starts

2026-05-01

Expected to finish

2026-09-01

Last updated by the study team

2026-03-04

Who can join

Age: 65 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 65 years or older
• Desiring to participate in voice therapy

You may not qualify if…

• Lesions or abnormalities of the larynx not attributable to normal aging
• Pre-existing renal disease
• Pre-existing liver disease
• Congestive heart failure
• Blood urea nitrogen (BUN), creatine, alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT) over reference range in the last 6 months
• Concurrent medication associated with reduced renal clearance (e.g. Nonsteroidal Anti-inflammatory Drugs (NSAIDs), metformin)
• History of prior vocal fold augmentation procedures
• Cognitive disability
• Unwillingness to participate in voice therapy

Where it is running

• NYU Langone Health — New York, New York, United States

Full record on ClinicalTrials.gov

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