A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Recruiting now · Phase 4

Conditions studied: Respiratory Function Loss, Respiratory Complication

In brief

The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.

Key facts

Study ID

NCT05856136

Run by

Mayo Clinic

People needed

69

Starts

2023-06-19

Expected to finish

2027-01-01

Last updated by the study team

2026-06-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system).

You may not qualify if…

• Patients who refuse research participation.
• Patients who are pregnant.
• Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).

Where it is running

• Mayo Clinic Minnesota — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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