Stimulation-Induced Changes in Fronto-Limbic Network

Recruiting now · Not applicable

Conditions studied: Epilepsy, Mental Disorders

In brief

The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, the results of which will be combined with results from the activity of each electrode during the emotion tasks to inform us of the nature of emotion processing in the brain and allow us to devise brain modulation protocols in the future.

Key facts

Study ID

NCT05854160

Run by

University of Alabama at Birmingham

People needed

30

Starts

2023-03-01

Expected to finish

2027-02-24

Last updated by the study team

2026-06-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1) implantation of sEEG electrodes for SOC epilepsy surgery evaluation
• 2) cognitive ability to perform simple tasks and to understand instructions
• 3) implanted electrodes in the amygdala and medial PFC regions
• 4) competency to understand and sign a written informed consent.

You may not qualify if…

• 1) an inability to complete the task

Where it is running

• Epilepsy Monitoring Unit UAB Hospital — Birmingham, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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