Acute Exercise on Brain Insulin Sensitivity
Completed · Not applicable
Conditions studied: Aging, Obesity, Insulin Resistance, Cognition, Cardiovascular Disease Risk
In brief
Dementia is a leading cause of death in the United States among aging adults. Brain insulin resistance has emerged as a pathologic factor affecting memory, executive function as well as systemic glucose control. Regular aerobic exercise decreases Alzheimer's Disease (AD) risk, in part, through changes in brain structure and function. However, there is limited data available on how exercise impacts brain insulin resistance in aging. This study will test the effect of acute exercise on brain insulin sensitivity in middle-aged to older adults. The study will also examine cognition and cardiometabolic health in relation to brain insulin sensitivity.
Key facts
- Study ID
- NCT05853913
- Run by
- Rutgers, The State University of New Jersey
- People needed
- 16
- Starts
- 2023-05-11
- Expected to finish
- 2025-03-25
- Last updated by the study team
- 2025-11-21
Who can join
Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female >/=40 and </=80 years old.
- Has a body mass index >/=25 and </=45 kg/m2.
- Physical Activity (<150 min of moderate/high intensity exercise per week)
You may not qualify if…
- Subjects who have not been weight stable (>2 kg weight change in past 3 months)
- Subjects who are smokers or who have quit smoking <1 years ago
- Subjects with abnormal estimated glomerular filtration rate (eGFR).
- Hypertriglyceridemic (>400 mg/dl) and hypercholesterolemic (>260 mg/dl) subjects
- Hypertensive (>160/100 mmHg)
- Subjects with a history of significant metabolic, cardiac, congestive heart failure, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or cancer that in the investigator's opinion would interfere with or alter the outcome measures or impact subject safety.
- Pregnant (as evidenced by positive urine pregnancy test) or nursing women
- Subjects with contraindications to participation in an exercise
- Current Pregnancy
- Currently taking active weight suppression medication (e.g. phentermine, orlistat, lorcaserin, naltrexone-bupropion in combination, liraglutide, benzphetamine, diethylpropion, phendimetrazine)
- Subjects currently taking medications that affect heart rate and rhythm (i.e. Ca++ channel blockers, nitrates, alpha- or beta-blockers).
- Known contraindications for MRI imaging
Where it is running
- Institute for Food, Nutrition, and Health — New Brunswick, New Jersey, United States
- Robert Wood Johnson University Hospital Clinical Research Center — New Brunswick, New Jersey, United States
- Rutgers University Loree Gymnasium — New Brunswick, New Jersey, United States
- Center for Advanced Human Brain Imaging Research — Piscataway, New Jersey, United States
Full record on ClinicalTrials.gov
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