Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)
Running, not enrolling · Phase 2
Conditions studied: Advanced Cancer, Metastatic Cancer, Malignant Neoplasm of Lung
In brief
This study will evaluate the efficacy of two dosing regimens of adagrasib (600 mg BID versus 400 mg BID) in patients with NSCLC with KRAS G12C mutation.
Key facts
- Study ID
- NCT05853575
- Run by
- Mirati Therapeutics Inc.
- People needed
- 200
- Starts
- 2024-02-01
- Expected to finish
- 2026-11-30
- Last updated by the study team
- 2026-08-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Local Institution - 105 — Kansas City, Missouri, United States
- Local Institution - 100 — Durham, North Carolina, United States
- Local Institution - 106 — Dallas, Texas, United States
- Local Institution - 181 — Salvador, Estado de Bahia, Brazil
- Local Institution - 177 — Porto Alegre, Rio Grande do Sul, Brazil
- Local Institution - 182 — Itajaí, Santa Catarina, Brazil
- Local Institution - 178 — Belo Horizonte, São Paulo, Brazil
- Local Institution - 102 — São Paulo, Brazil
- Local Institution - 175 — São Paulo, Brazil
- Local Institution - 527 — Zagreb, City of Zagreb, Croatia
- Local Institution - 529 — Rijeka, Primorje-Gorski Kotar County, Croatia
- Local Institution - 559 — Grenoble, Auvergne-Rhône-Alpes, France
- Local Institution - 556 — Pessac, Gironde, France
- Local Institution - 553 — Saint-Herblain, Loire-Atlantique, France
- Local Institution - 554 — Angers, Maine-et-Loire, France
- Local Institution - 552 — Lorient, Morbihan, France
- Local Institution - 555 — Nantes, Pays de la Loire Region, France
- Local Institution - 557 — Poitiers, Poitou-Charentes, France
- Local Institution - 561 — Nice, Provence-Alpes-Côte d'Azur Region, France
- Local Institution - 551 — Marseille, Rhône, France
- Local Institution - 560 — Villefranche-sur-Saône, Rhône, France
- Local Institution - 562 — Paris, France
- Local Institution - 558 — Quimper, France
- Local Institution - 550 — Saint-Mandé, France
- Local Institution - 101 — Santa Rosa, California, United States
Full record on ClinicalTrials.gov
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