Assessment of PaO2/FiO2 Ratio Pre and POst INTubation
Running, not enrolling
Conditions studied: Acute Hypoxemic Respiratory Failure
In brief
We designed this study to dtermine whether invasive mechanical ventilation (MV) would have an impact on the reclassification of patients with acute hypoxemic respiratory failure (AHRF) -treated previously with non-invasive respiratory support- into categories of severity (mild, moderate, and severe). Our hypothesis is that the assessment of PaO2/FiO2 ratio on PEEP greater or equal to 5 cmH2O after intubation, in patients labeled as mild/moderate/severe AHRF while on non-invasive respiratory support, would identify that a marked proportion of patients would change the degree of severity after a brief period of invasive MV
Key facts
- Study ID
- NCT05853068
- Run by
- Hospital Universitario de Gran Canaria Doctor Negrín
- People needed
- 400
- Starts
- 2023-04-29
- Expected to finish
- 2025-11-30
- Last updated by the study team
- 2025-08-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients meeting criteria for AHRF while they are on non-invasive respiratory support.
- We will only include patients who had arterial blood gases (ABG) within a time-frame of the last 5 hours of NIV and the first 5 hours of invasive MV.
- We will only include patients treated with high-flow oxygen nasal cannula (HFNC), or continuous positive airway pressure (CPAP), or bilevel positive pressure (BiPAP).
You may not qualify if…
- Patients who never required HFNC, or CPAP, or BiPAP before intubation.
- Patients with no ABG during the last 5 hours of NIV before intubation.
- Patients with no ABG during the first 5 hours after initiation of invasive MV.
- Patients treated with inhaled pulmonary vasodilator only before or only after intubation.
Where it is running
- Rush University Medical Center — Chicago, Illinois, United States
- Jesús Villar — Las Palmas de Gran Canaria, Las Palmas, Spain
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.