Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
Recruiting now · Phase 4
Conditions studied: Depression in Old Age, Fragility Fracture
In brief
The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture. The main questions it aims to answer are: * What are the obstacles to enrolling patients and prescribing anti-depressants among older adults? * Is it possible to start prescribing SNRI medication upon discharge? * What is the prevalence of depressive symptoms amongst patients with different types of injuries and weightbearing status? * What is a transition of care plan for patients who have geriatric depression and require further care? Participants will: * Undergo screening using the Geriatric Depression Scale * Start on Duloxetine 30mg daily at time of discharge * Report medication compliance and complete re-screening monthly * Complete patient reported outcome measures and 3 months, 6 months, and 1 year * Receive a referral to behavioral health, primary care, or psychiatrist for evaluation if they screen positive at any timepoint
Key facts
- Study ID
- NCT05851898
- Run by
- Wake Forest University Health Sciences
- People needed
- 100
- Starts
- 2024-04-08
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-03-12
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Geriatric (greater than or equal to 65 years old)
- Lower extremity fragility fractures managed operatively
You may not qualify if…
- Polytrauma
- Pathological fractures
- Patients on hospice
- Patients with previously diagnosed psychiatric disorders
- Patients with previously diagnosed dementia
- Patients already taking Selective serotonin reuptake inhibitors (SSRI)s and Serotonin- norepinephrine reuptake inhibitors (SNRI)s
- Patients already taking mood stabilizing medication
- Unable to provide informed consent (no use of a legal authorized representative)
- Patients with pre-existing life limiting diagnoses (cancer, etc.)
Where it is running
- Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
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