Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive Brain Stimulation Treatment
Recruiting now · Not applicable
Conditions studied: Lewy Body Disease, Healthy Aging
In brief
Lewy body diseases (LBDs) represents a group of neurodegenerative disorders characterized by the abnormal accumulation of aggregates of α-synuclein protein leading to the formation of Lewy bodies (LB) and Lewy neurites resulting in cell death. LBDs consists of two major clinical entities - Parkinson's disease (PD) and dementia with LB (DLB). Vast majority of patients with LBDs either already have mild cognitive impairment (MCI) at the time of the diagnosis or will develop it during the course of the disease. Language dysfunctions in LBDs patients with MCI are often unrecognized, which are difficult to treat, but even subtle changes might lead to impairment of social and occupational functioning with profound effect on their quality of lives. Current pharmacological or surgical strategies are effective for tackling the motor issues of LBDs with very limited effects on other symptoms such as language dysfunctions. Therefore, non-pharmacological approaches are gaining more attention. One of these non-pharmacological strategies is the use of noninvasive brain stimulation (NIBS) techniques that are able to modulate the brain functions with the effects on human nervous system plasticity. In this proposed project the investigators aim to first describe specific alterations in the language domain in LBDs patients with MCI as compared to healthy controls (HC) and identify the neural underpinnings of these changes using novel combination of advanced multimodal imaging techniques and various analytical methods. Secondly, the investigators aim to use NIBS as a supervised and individualized home-based therapeutical approach to tackle the language dysfunctions.
Key facts
- Study ID
- NCT05847985
- Run by
- Masaryk University
- People needed
- 90
- Starts
- 2023-05-01
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-02-04
Who can join
Age: 60 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- right-handedness
- Czech as their first language
- age (60-80 years)
- presence of PD-MCI (Litvan et al. 2012) or MCI-LB (McKeith et al. 2020) for LBD subjects
You may not qualify if…
- cardio pacemaker
- any MRI-incompatible metal in the body
- epilepsy
- any diagnosed psychiatric disorders
- alcohol/drug abuse
- for HC group the presence of LBDs or other neurodegenerative disorder or MCI/dementia
Where it is running
- Masaryk University CEITEC — Brno, Czechia (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.