Plasma cfDNA Fragmentomics for Early pNET Detection and Differential Diagnosis of Solid Pancreatic Tumors

Recruiting now

Conditions studied: Pancreatic Neuroendocrine Tumor, Solid Pancreatic Neoplasms

In brief

This prospective study aims to evaluate the sensitivity and specificity of an integrated model using fragmentomic profiles of plasma cell-free DNA for early detection of pancreatic neuroendocrine tumors and differential diagnosis of solid pancreatic tumors.

Key facts

Study ID

NCT05847855

Run by

Fudan University

People needed

1000

Starts

2023-02-27

Expected to finish

2026-06-30

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 and above, regardless of gender;
• Histopathological diagnosis with non-functional pancreatic neuroendocrine tumor, pancreatic ductal adenocarcinoma or solid pseudopapillary tumor;
• Not receiving any anti-tumor treatment before surgery, including chemotherapy, embolization, ablation, radiotherapy, and molecular targeted therapy;
• No obvious surgical contraindications;
• Able to comply with research plans, follow-up plans, and other protocol requirements;
• Voluntary participation and signed informed consent.

You may not qualify if…

• Pathological diagnosis was not pancreatic neuroendocrine tumor, pancreatic ductal adenocarcinoma or solid pseudopapillary tumor;
• Currently diagnosed with other types of tumors or any cancer history;
• Diagnosed with familial syndromes;
• Receiving anti-tumor treatment before surgery, including chemotherapy, embolization, ablation, radiotherapy, and molecular targeted therapy;
• Ongoing fever or recipient of anti-inflammation therapy within 14 days prior to study blood draw;
• Recipient of blood transfusion within 30 days prior to study blood draw;
• Recipient of organ transplant or prior non-autologous (allogeneic) bone marrow or stem cell transplant;
• Poor health condition and not suitable for blood draw;
• Any other disease/condition deemed not suitable for study enrollment by researcher.

Where it is running

• Fudan University shanghai cancer center — Shanghai, Shanghai Municipality, China (enrolling)
• West China Hospital, Sichuan University — Chengdu, Sichuan, China (enrolling)

Full record on ClinicalTrials.gov

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