Tau Networks in Psychotic Alzheimer's Disease
Recruiting now
Conditions studied: Alzheimer Disease, Alzheimer Disease With Delusions, Alzheimer Disease With Psychosis
In brief
This research project aims to understand the brain mechanisms behind the manifestation of psychotic symptoms in Alzheimer´s disease (AD), and nature of the unique relationship with tau pathology. Amongst the cognitive manifestations of psychosis are impairments related to frontal circuits (social cognition, working memory and executive function deficits). The investigator's previous work suggests a role of tau pathology (one of the hallmarks of AD neuropathology) in the manifestation of psychosis in AD. However, the cerebral mechanisms that underly this association remain poorly understood. The overarching aim of the study is is to investigate the mechanisms by which tau network pathology may promote the presentation of psychosis in AD.
Key facts
- Study ID
- NCT05847192
- Run by
- Northwell Health
- People needed
- 91
- Starts
- 2023-04-13
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2026-04-08
Who can join
Age: 65 and older, up to 85. Sex: any. Healthy volunteers: accepted.
Where it is running
- The Feinstein Institutes for Medical Research — Manhasset, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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