PRogram to Improve Stress-levels and Enhance Memory

Completed · Not applicable

Conditions studied: Mild Cognitive Impairment

In brief

This is a pilot study with the objective to examine if an in-person and a remote multi-component intervention program can improve chronic stress, vascular measures, and executive function among African American and White patients with Mild Cognitive Impairment. Researchers plan to enroll 45 participants with over-recruitment of African American patients. Participants will be recruited to participate in PRogram to Improve Stress-levels and Enhance Memory (PRISEM) (i.e., remote lifestyle intervention program). The participants will be asked to participate in group-based and/or individual activities that focus on improving health education, nutrition, physical activity, cognitive health, stress levels, and overall well-being. The duration of the study for all participants will be 12 months with 3 study visits. At each study visit, the following measures will be assessed: psychosocial, behavioral, vascular/physical, and executive function.

Key facts

Study ID

NCT05845918

Run by

Emory University

People needed

45

Starts

2023-02-21

Expected to finish

2026-05-01

Last updated by the study team

2026-05-28

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 50 years or older
• Fluency in English
• African American or White
• MCI will be defined as subjective memory complaints with a Montreal Cognitive Assessment (MoCA) 19- 25
• Prior diagnosis of MCI
• Participants would be sedentary at baseline (self-report of <30 minutes of structured physical activity <3 times per week in the last 6 months) and have poor Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) diet scores (using the MIND diet screener)

You may not qualify if…

• Dementia diagnosis or reversible causes of dementia (e.g., if the patient has hypothyroidism or low vitamin B12 that is contributing to the subject's cognitive impairment)
• Active medical or psychiatric diseases that in the judgment of the investigator would affect the safety of the subject or scientific integrity of the study (e.g., actively manic patient)
• Uncontrolled medical conditions, such as congestive heart failure, reflected by poor exercise tolerance and shortness of breath
• Any physical ailment, such as stroke with residual impairment, that is a barrier to performing study procedures and attending sessions
• History of brain lesions, stroke, or major head trauma in the past year
• Those who are unable to demonstrate that they understood the details of the study (i.e., lack of decisional- capacity to consent) or linguistic limitations
• Pregnant women, prisoners, and adults unable to consent

Where it is running

• Emory Goizueta Alzheimer's Disease Research Center (GADRC) — Atlanta, Georgia, United States
• Emory Dunwoody Clinic — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.