Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- CloPidogREl for Primary preVENTION (HOST-PREVENTION)

Recruiting now · Phase 4

Conditions studied: Coronary Artery Disease

In brief

The investigators will evaluate the efficacy and safety of clopidogrel for primary prevention in patients diagnosed with coronary atherosclerosis on imaging that did not require revascularization therapy. The trial will test the hypothesis that clopidogrel is beneficial in preventing major adverse cardiovascular and cerebrovascular events (MACCE) in patients with subclinical coronary atherosclerosis identified on imaging.

Key facts

Study ID

NCT05845489

Run by

Seoul National University Hospital

People needed

11086

Starts

2023-03-22

Expected to finish

2031-12-31

Last updated by the study team

2025-12-31

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female aged ≥40 years
• Patients with subclinical coronary atherosclerosis identified from coronary CT angiography or coronary angiography within 2 years without clinical events after an imaging study
• Without significant coronary artery stenosis (Diameter stenosis >50%), which needs revascularization
• Agreement to give written informed consent

You may not qualify if…

• A history of a diagnosed cardiovascular or cerebrovascular disease (Type1 myocardial infarction, heart failure, peripheral artery disease, stroke, transient ischemic attack, carotid artery stenosis>50%, carotid artery intervention)
• A history of coronary artery intervention or coronary artery bypass graft surgery, which needs chronic maintenance of antiplatelet therapy
• Absolute contraindication or allergy to clopidogrel
• Patients receiving anticoagulants for other comorbidities
• A history of Bleeding diathesis, known coagulopathy, or major bleeding, BARC class ≥3, resulting in the stop of antiplatelet agents
• Planned surgery or intervention which needs to stop antiplatelet agents ≥1 month
• Presence of non-cardiac comorbidity with life expectancy ≤ 5 years at randomization
• Females with pregnancy or breast-feeding
• Patients who are thought to be inappropriate for the trial based on physicians' decision

Where it is running

• Andong Hospital — Andong, South Korea (enrolling)
• Dong-A University Hospital — Busan, South Korea (enrolling)
• Inje University Busan Paik Hospital — Busan, South Korea (enrolling)
• Kosin University Gospel Hospital — Busan, South Korea (enrolling)
• Pusan National University Hospital — Busan, South Korea (enrolling)
• Gyeongsang National University Changwon Hospital — Changwon, South Korea (enrolling)
• Soonchunhyang University Cheonan Hospital — Cheonan, South Korea (enrolling)
• Soonchunhyang University Cheonan Hospital — Cheonan, South Korea (enrolling)
• Soonchunhyang University Cheonan Hospital — Cheonan, South Korea (enrolling)
• Chungbuk National University Hospital — Cheongju-si, South Korea (enrolling)
• Hallym University Chuncheon Sacred Heart Hospital — Chuncheon, South Korea (enrolling)
• Kangwon National University Hospital — Chuncheon, South Korea (enrolling)
• Kangwon National University Hospital — Chuncheon, South Korea (enrolling)
• Keimyung University Dongsan Hospital — Daegu, South Korea (enrolling)
• Yeungnam University Medical Center — Daegu, South Korea (enrolling)
• Chungnam National University Hospital — Daejeon, South Korea (enrolling)
• Eulji University Hospital, Daejeon — Daejeon, South Korea (enrolling)
• Gangneung Asan Hospital — Gangneung, South Korea (enrolling)
• Chonnam National University Hospital — Gwangju, South Korea (enrolling)
• Chonnam National University Hospital — Gwangju, South Korea (enrolling)
• Kwangju Christian Hospital — Gwangju, South Korea (enrolling)
• Chung-Ang University Gwangmyeong Hospital — Gyeonggi-do, South Korea (enrolling)
• Eulji University Hospital, Uijeongbu — Gyeonggi-do, South Korea (enrolling)
• Hallym University Dongtan Sacred Heart Hospital — Gyeonggi-do, South Korea (enrolling)
• Seoul National University Hospital — Seoul, Other, South Korea (enrolling)

Full record on ClinicalTrials.gov

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