Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy
Recruiting now · Phase 3
Conditions studied: Radiation Retinopathy, Visual Impairment
In brief
This randomized controlled trial will evaluate the effect of intravitreal faricimab or fluocinolone acetonide (FAc) intravitreal implant compared with observation on long-term visual acuity following treatment of choroidal melanoma with iodine-125 plaque brachytherapy.
Key facts
- Study ID
- NCT05844982
- Run by
- Jaeb Center for Health Research
- People needed
- 600
- Starts
- 2023-11-21
- Expected to finish
- 2029-12-26
- Last updated by the study team
- 2026-07-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Byers Eye Institute at Stanford University — Palo Alto, California, United States (enrolling)
- Retina Consultants — Manchester, Connecticut, United States (enrolling)
- Retina Associates of Florida, LLC — Tampa, Florida, United States (enrolling)
- Emory Eye Center — Atlanta, Georgia, United States (enrolling)
- Northwestern Memorial Group — Chicago, Illinois, United States (enrolling)
- IL Eye and Ear Infirmary-University of Illinois at Chicago — Chicago, Illinois, United States (enrolling)
- Midwest Eye Institute — Indianapolis, Indiana, United States (enrolling)
- University of Iowa Department of Ophthalmology and Visual Sciences — Iowa City, Iowa, United States (enrolling)
- Foundation for Vision Research and Retina Specialists of Michigan, P.C. — Grand Rapids, Michigan, United States (enrolling)
- Associated Retinal Consultants, P.C. — Royal Oak, Michigan, United States (enrolling)
- Mayo Clinic — Rochester, Minnesota, United States (enrolling)
- Washington University Ophthalmology — St Louis, Missouri, United States (enrolling)
- Retina Research Institute, LLC — St Louis, Missouri, United States (enrolling)
- The Cleveland Clinic Foundation DBA Cleveland Clinic Lerner College of Medicine — Celveland, Ohio, United States (enrolling)
- Oregon Health & Science University — Portland, Oregon, United States (enrolling)
- Retina-Vitreous Consultants, Inc. — Monroeville, Pennsylvania, United States (enrolling)
- Wills Eye Hospital — Philadelphia, Pennsylvania, United States (enrolling)
- Pittsburgh Clinical Trial Consortium — Sewickley, Pennsylvania, United States (enrolling)
- Retina Consultants of Carolina, PA — Greenville, South Carolina, United States (enrolling)
- Southeastern Retina Associates — Hixson, Tennessee, United States (enrolling)
- Tennessee Retina, PC — Nashville, Tennessee, United States (enrolling)
- Retina Consultants of Texas, PA — Bellaire, Texas, United States (enrolling)
- UT Southwestern Medical Center — Dallas, Texas, United States (enrolling)
- Texas Retina Associates — Lubbock, Texas, United States (enrolling)
- The Board of Regents of the University of Wisconsin System — Madison, Wisconsin, United States (enrolling)
Full record on ClinicalTrials.gov
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