The ICU LIBERATION Study

Recruiting now

Conditions studied: Acute Respiratory Distress Syndrome, Post Intensive Care Syndrome, Treatment Compliance, Quality of Life

In brief

Acute respiratory distress syndrome (ARDS) is a condition associated with hypoxemia due to noncardiogenic causes and results in high mortality. However, the epidemiology and treatment strategy for ARDS may have changed significantly due to the accumulation of a large body of knowledge, following the two-year pandemic of the novel coronavirus (SARS-CoV-2) of which the primary manifestation is ARDS. To improve the quality of ICU care that patients receive after admission to the ICU, a variety of academic societies, including the Japanese Society of Intensive Care Medicine and the Society of Critical Care Medicine, are currently developing evidence-based guidelines and consensus guidelines and statements regarding ABCDEF bundles, nutritional therapy, ICU diary. The ABCDEF bundle, nutritional therapy, and ICU diary have been developed and are being promoted for implementation in hospitals around the world. The implementation of evidence-based ICU care is strongly recommended, especially for patients with acute respiratory distress syndrome who frequently require ventilators to maintain their lives, because their patient outcomes are worse than those who were admitted to ICU with other causes. However, there is still little evidence on how the quality of ICU care (compliance rate) correlates with patient prognosis and outcomes, and there are currently no clear goals or indicators for the ICU care we should develop. This study aims to investigate the epidemiology and treatments given to the patients and evaluate the implementation of evidence-based ICU care and its association with the outcomes of patients with acute respiratory distress syndrome admitted to the ICU. The contents of mechanical ventilation settings, respiratory conditions, and the evidence-based ICU care, such as analgesia, sedation, rehabilitation, and nutrition, given to the patients will be collected in a daily basis. Aim 1: Epidemiology Aim 2: Treatments Aim 3: Evidence-based ICU care Aim 4: ARDS related Post Intensive Care Syndrome

Key facts

Study ID: NCT05844579
Run by: Japanese Society for Early Mobilization
People needed: 1000
Starts: 2023-06-01
Expected to finish: 2031-12-31
Last updated by the study team: 2024-09-19

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients on an invasive or non-invasive ventilator within 24 hours of ICU admission
Patients who are expected to be on an invasive and/or non-invasive ventilator for more than 48 hours in total
Patients who meet the diagnosis of ARDS within 24 hours of ICU admission

You may not qualify if…

Patients who are younger than 16 years old
Patients with terminal conditions at the time of ICU admission
Patients who have been admitted to the ICU with a terminal care policy or who are expected to be admitted to the ICU with a terminal care policy within 24 hours of admission to the ICU
Patients who have expressed their refusal to have their clinical data used in research.

Where it is running

LIBERATION Study Research Office — Tokyo, Japan (enrolling)

Full record on ClinicalTrials.gov

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