Coronary Flow During Rapid Heart Rates

Recruiting now

Conditions studied: Ventricular Tachycardia, Coronary Artery Disease, Heart Failure, Coronary Microvascular Dysfunction, Coronary Microvascular Disease

In brief

The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1. What impact does coronary artery disease have on the ability for a patient to tolerate VT? 2. Does treatment of coronary artery disease with stents improve the tolerability of VT? Participants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure, coronary pressure and coronary flow made during pacing at a range of heart rates.

Key facts

Study ID

NCT05841199

Run by

Imperial College London

People needed

70

Starts

2023-08-01

Expected to finish

2026-06-02

Last updated by the study team

2026-03-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Able to give valid consent
• Referred for coronary angiography or coronary angioplasty
• Suitable for percutaneous physiological interrogation and PCI when clinically indicated

You may not qualify if…

• Unable to give valid consent
• Pregnant or breastfeeding women
• Unstable coronary artery disease (acute coronary syndrome)
• Severe multivessel coronary artery disease suitable for coronary artery bypass grafting
• Severe heart valve disease
• Severe (NYHA IV) heart failure

Where it is running

• Imperial College NHS Foundation Trust — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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