Adapted Physical Activity Program (APA) for Effort Rehabilitation of Children and Teenagers With Marfan Syndrome

Recruiting now · Not applicable

Conditions studied: Marfan Syndrome

In brief

This research study aims to evaluate the effect of a 6-month adapted physical activity program (APA) on the endurance capacities (evaluated as the maximum oxygen consumption \[VO2 peak\] on a cardiopulmonary exercise test) of children and adolescents with Marfan syndrome or related.

Key facts

Study ID

NCT05838235

Run by

University Hospital, Toulouse

People needed

30

Starts

2023-04-24

Expected to finish

2028-10-01

Last updated by the study team

2026-03-03

Who can join

Age: 7 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Genetically confirmed Marfan syndrome or related syndrome
• Girl or boy aged 7 to 17
• Informed and written consent signed by at least one of the two holders of parental authority
• Patient affiliated to a social security scheme or equivalent

You may not qualify if…

• Cardiac contraindications to the APA program:
• Severe aortic dilation (aortic diameter > 45 mm)
• and/or left ventricular failure (left ventricular ejection fraction <45%)
• and/or severe mitral leakage ≥ grade 3
• Pregnancy

Where it is running

• CHU Toulouse — Toulouse, France (enrolling)

Full record on ClinicalTrials.gov

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