Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients

Recruiting now

Conditions studied: Extubation

In brief

Because Propofol is the primary "anesthetic agent," and inhalational agents remain in trace quantities at the end of the procedure Sevoflurane initiated intravenous anesthesia (SIIVA) or not present at all Total intravenous anesthesia (TIVA) it is likely that different criteria may be predictive of extubation success in these patients compared to inhalational anesthesia.

Key facts

Study ID

NCT05837936

Run by

Wake Forest University Health Sciences

People needed

600

Starts

2023-03-28

Expected to finish

2028-03-01

Last updated by the study team

2025-12-18

Who can join

Age: any, up to 9. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pediatric patients <10 years of age
• Undergoing elective or emergency surgery with planned airway instrumentation with an endotracheal tube (ETT)
• Patients having general anesthesia with a planned SIIVA or TIVA technique
• Patients with an end tidal agent concentration of Sevoflurane<0.1% at the time of emergence and extubation
• following sevoflurane induction to place IV

You may not qualify if…

• History of home oxygen use or ventilator dependence
• Patients with cyanotic congenital heart disease
• Patients undergoing anesthesia for imaging procedures alone
• Patients intended to be managed with supraglottic airway
• Patients having an anesthesia time < 30 minutes
• Monitored Anesthesia Care (not general anesthesia)
• Patients with contraindication to receiving Propofol (i.e. mitochondrial myopathy)

Where it is running

• Atrium Health Wake Forest Baptist — Winston-Salem, North Carolina, United States (enrolling)
• Perth Children's Hospital — Perth, Australia

Full record on ClinicalTrials.gov

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