Pragmatic Evaluation of Performance and Safety of the Anchorsure® Transvaginal Device for Surgical Treatment of Apical Prolapse in Women

Recruiting now

Conditions studied: Prolapse; Female, Prolapse Uterovaginal, Prolapse; Cervix

In brief

Pelvic Organ Prolapse affects 50% of parous women, and apical prolapse is one of the most common types of prolapse. Treatment for apical prolapse ranges from observation, non-surgical treatment or surgical repair. An anchoring device can reduce dissection and operative time and is meant to provide strong fixation whilst minimizing potential postoperative pain by avoiding neurovascular injuries. These potential advantages must be evaluated in terms of performance and safety. This cohort study will be on patients undergoing sacrospinous fixation with the Anchorsure® system with a follow-up of 36 months.

Key facts

Study ID

NCT05836844

Run by

Centre Hospitalier Universitaire de Nīmes

People needed

120

Starts

2023-05-11

Expected to finish

2028-06-01

Last updated by the study team

2025-11-17

Who can join

Age: 50 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women with pelvic organ prolapse with leading edge at or beyond the hymen as confirmed by the pelvic organ prolapse quantification system (POP-Q), i.e. Ba ≥ -1 cm for the anterior compartment, and/or Bp ≥ -1 cm for the posterior compartment, and/or C ≥ -1 cm for the apical compartment including recurrence.
• Women due for POP surgery using the Anchorsure System® for apical prolapse suspension with or without concomitant native tissue repair, with or without concomitant hysterectomy and with or without concomitant sling for stress urinary incontinence.
• All women who have not indicated any objection to participating in the study.
• All women who have been correctly informed.

You may not qualify if…

• Patient taking part or having taken part in a device or drug interventional study within the last three months (except for VIGI-MESH national registry).
• Patients due for pelvic organ prolapse repair without apical suspension or with anything other than native tissue repair and the Anchorsure System®.
• Patients with uncontrolled diabetes mellitus.
• Patients with active non-controlled or chronic gynaecologic or urinary tract infection and/or local tissue necrosis.
• Patients with ongoing pelvic organ cancer (e.g. uterine, ovarian, bladder, cervix …).
• Patients with a history of radiotherapy in the pelvic area.
• Patients on therapy with immunosuppressive or immunomodulatory treatment within the previous month.
• patients under ongoing oral anticoagulant therapy.
• Patients with stage 0 and 1 pelvic organ prolapse at the time of surgery
• Patients with a preoperative infection contraindicating the surgery

Where it is running

• La Rochelle General Hospital — La Rochelle, France (enrolling)
• Lille University Hospital — Lille, France (enrolling)
• Kremlin-Bicêtre Hospital — Paris, France (enrolling)
• Clinique Sainte-Anne — Strasbourg, France (enrolling)

Full record on ClinicalTrials.gov

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