Low-intensity Focused Ultrasound and Autonomic Response

Enrolling by invitation · Not applicable · Has a placebo group

Conditions studied: Autonomic Dysfunction

In brief

Studying the effects of Low Intensity Focused Ultrasound (LIFU) to the dorsal posterior insula (dPI) and dorsal anterior cingulate cortex (dACC) on autonomic control using a test to probe the autonomic system. A cold pressor task will be performed pre and post LIFU application. Physiologic recordings will be recorded throughout.

Key facts

Study ID

NCT05834829

Run by

Virginia Polytechnic Institute and State University

People needed

80

Starts

2024-02-22

Expected to finish

2027-12-30

Last updated by the study team

2026-06-08

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Does not meet exclusion criteria.

You may not qualify if…

• The exclusion criteria below are regularly implemented in MRI, CT, and EEG experiments for the safety of the subjects and for data quality assurance.
• Claustrophobia (scanning environment may be uncomfortable).
• Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
• Contraindications to CT: pregnancy
• Active medical disorder or treatment with potential central nervous system (CNS) effects (e.g. Alzheimer's) -
• History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor)
• History of head injury resulting in loss of consciousness for >10 minutes.
• History of alcohol or drug dependence (through self-report).
• History of cardiac disease
• A current or prior use of any cardiac medication (e.g. beta blockers or other anti-arrhythmics)
• A history of diabetes mellitus or use of diabetic medications (e.g. metformin).

Where it is running

• Fralin Biomedical Research Institute at VTC — Roanoke, Virginia, United States

Full record on ClinicalTrials.gov

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