Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nephropathy

Completed · Phase 2 · Has a placebo group

Conditions studied: IgA Nephropathy, Immunoglobulin A Nephropathy

In brief

The ASSIST study was a phase 2, double-blind, placebo-controlled crossover study to evaluate the safety and efficacy of atrasentan vs. placebo in subjects with IgA nephropathy (IgAN) while on background standard of care therapy and an SGLT2 inhibitor (SGLT2i).

Key facts

Study ID

NCT05834738

Run by

Novartis Pharmaceuticals

People needed

54

Starts

2023-07-20

Expected to finish

2025-10-29

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Legal adults (per local and country specifications) ≥ 18 years of age at the time of signing the informed consent form (ICF) prior to initiation of any study specific activities/procedures.
• Biopsy-proven IgA nephropathy.
• Receiving a maximally tolerated and stable dose of a RASi for at least 12 weeks prior to screening. Investigator discretion should be used in determining maximally tolerated and optimized dose.
• eGFR of at least 30 mL/min/1.73 m\^2 at screening based on the 2021 CKD-EPI equation.
• Willing to agree to highly effective forms of contraception, as specified in the protocol, throughout the study and for up to 1 month afterward. In WOCBP, use of hormonal contraceptive agents must have been started at least 1 month prior to baseline.
• Willing and able to provide informed consent and comply with all study requirements.
• Inclusion Criteria for SGLT2i stable subjects
• Receiving a stable dose of an SGLT2i for at least 8 weeks prior to screening
• Must have a 24-hour urine protein of >0.5 grams/day.
• Inclusion Criteria for Run-In Subjects
• Must have a 24-hour total urine protein of >0.85 grams/day at screening
• Willing to participate in an 8-week run-in period with an SGLT2i (per Investigator choice)
• Additional Inclusion Criteria for Run-in Subjects at the end of Run-In
• Must have completed the 8-week run-in period on a stable and well tolerated dose of an SGLT2i
• Must have a 24-hour total urine protein of >0.5 grams/day confirmed at the Run-in Week 8 visit.
• Must have an eGFR of ≥ 30 mL/min/1.73 m\^2 based on the CKD-EPI equation at their Run-in Week 8 visit.

You may not qualify if…

• Current diagnosis with another chronic kidney disease, including diabetic kidney disease.
• History of kidney transplantation or other organ transplantation.
• Use of systemic immunosuppressant medications, such as steroids, for more than 2 weeks in the past 3 months.
• Blood pressure above 150 mmHg systolic or 95 mmHg diastolic as evaluated by the Investigator.
• Known history of heart failure or prior hospital admissions for conditions relating to fluid overload that in the opinion of the Principal Investigator or Sponsor might confound the results of the study or pose additional risk to the participant by their participation in the study.
• Clinically significant history of liver disease as assessed by the Investigator.
• Hemoglobin below 9 g/dL as measured by the Investigator or prior history of blood transfusion for anemia within the past 3 months.
• Malignancy within the past 5 years. Exceptions to this criteria include nonmelanoma skin cancer and curatively treated cervical carcinoma in situ.
• For women, pregnancy, breast feeding, or intent to become pregnant during the study. and at least 1 month afterward.
• For men, intent to father a child or donate sperm during the study.
• Have received any investigational agent or approved treatment for IgAN (other than a RAS inhibitor) including SGLT2i (except for subjects in the SGLT2i stable stratum) within 1 month (or 5 half-lives of the agent, whichever is longer) prior to Screening. If the investigational agent is a cytotoxic or immunosuppressive agent then this washout period is 6 months.

Where it is running

• University of Alabama at Birmingham (UAB) - The Kirklin Clinic (TKC) - Nephrology Clinic — Birmingham, Alabama, United States
• Fides Clinical Research — Atlanta, Georgia, United States
• NANI Research — Oak Brook, Illinois, United States
• Tufts Medical Center — Boston, Massachusetts, United States
• University of North Carolina at Chapel Hill - Nephrology and Hypertension — Chapel Hill, North Carolina, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• The St. George Hospital — Kogarah, New South Wales, Australia
• Prince of Wales Hospital — Sydney, New South Wales, Australia
• Monash Health- Monash Medical Centre — Melbourne, Victoria, Australia
• Sunshine Hospital — St Albans, Victoria, Australia
• NUPEC Cardio — Belo Horizonte, Minas Gerais, Brazil
• Santa Casa de Misericordia de Porto Alegre — Porto Alegre, Rio Grande do Sul, Brazil
• Universidade Federal de Sao Paulo — São Paulo, São Paulo, Brazil
• Hospital das Clinicas da Faculdade de Medicina da USP — São Paulo, São Paulo, Brazil
• Hopsital Sultanah Aminah Johor Bharu (HSAJB) - Bangunan Bakawali Heodialysis Centre — Johor Bahru, Johor Darul Takzim, Malaysia
• Universiti Kebangsaan Malaysia (UKM) - Medical Centre (Pusat Perubatan) (Hospital Canselor Tuanku Muhriz (HCTM)) — Cheras, Kuala Lumpur, Malaysia
• University Malaya Medical Centre — Kuala Lumpur, Kuala Lumpur, Malaysia
• Hospital Raja Permaisuri Bainun (HRPB) — Ipoh, Perak, Malaysia
• Dong-A University Medical Center (Dong-A University Hospital) — Busan, Busan, South Korea
• Soon Chun Hyang Central Medical Center (SCHMC) - Soon Chun Hyang University Hospital — Cheonan, Chungnam-Do, South Korea
• Hallym University Sacred Heart Hospital — Anyang-si, Gyeonggi-do, South Korea
• Chung-Ang University College — Seoul, Seoul, South Korea
• Hospital Torrecardenas — Almería, Spain
• Hospital del Mar — Barcelona, Spain
• Hospital del Vall d´Hebron — Barcelona, Spain

Full record on ClinicalTrials.gov

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