Investigating Real-world Stress-related Mechanisms in Heavy Cannabis Users

Completed · Not applicable

Conditions studied: Cannabis Use, Cannabis, Cannabis Abuse

In brief

This research project proposes a novel approach to elucidate the biological adaptations associated with heavy cannabis use and to assess whether such adaptations are predictive of higher cannabis craving in response to both cannabis cues and stressors.

Key facts

Study ID: NCT05833230
Run by: Yale University
People needed: 54
Starts: 2023-06-01
Expected to finish: 2025-02-26
Last updated by the study team: 2025-03-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Cannabis-using men and women who:
have a past-year pattern of 1 or more cannabis use episodes per week
do not meet criteria for any other substance use disorders other than mild Cannabis and Alcohol Use Disorder
are at least 18 years old
are fluent in English
can provide negative alcohol breathalyzer and only positive for cannabis at all visits.
can provide written informed consent.

You may not qualify if…

Individuals will be excluded if they:
meeting current or past for major psychiatric disorders, other than depression or anxiety disorder;
meeting criteria for a current Substance Use Disorder other than mild Cannabis Use Disorder and Alcohol Use Disorder;
any significant current medical conditions requiring medication, including neurological, renal, thyroid, cardiovascular, liver, endocrine, or immune conditions
current use of medications that interfere with hypothalamic-pituitary-adrenal axis response
women who are pregnant, lactating, peri-/post-menopausal, or with hysterectomies
current use of psychotropic drugs other than antidepressants.

Where it is running

Yale Stress Center — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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