Patient Characteristics and Treatment Patterns From Early Crizanlizumab Use in Real-world Setting: Preliminary Analysis From Select Sickle Cell Centers
Completed
Conditions studied: Sickle Cell Disease
In brief
This was a retrospective cohort study using secondary data from member sites of the National Alliance of Sickle Cell Centers (NASCC) with at least five patients who initiated crizanlizumab. Patients who were prescribed crizanlizumab were included in the cohort.
Key facts
- Study ID
- NCT05833022
- Run by
- Novartis Pharmaceuticals
- People needed
- 297
- Starts
- 2021-07-30
- Expected to finish
- 2022-04-18
- Last updated by the study team
- 2023-04-27
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Any patient with diagnosis of SCD based on high-performance liquid chromatography (HPLC) or hemoglobin electrophoresis at treating institution
- Treatment order for crizanlizumab; Index date was defined as the date for the first crizanlizumab treatment
- At least 12 months of available electronic medical record (EMR) data pre-index date (baseline)
- Patients must have received at least one dose of crizanlizumab
- For inclusion in pre/post analysis of effectiveness, patients must have received at least 6 doses of medication. The rates could be annualized if total post-index time was <12 months.
You may not qualify if…
- None specified
Where it is running
- University of Alabama Birmingham — Birmingham, Alabama, United States
- Cristiana Care — Wilmington, Delaware, United States
- All Children's Hospital — St. Petersburg, Florida, United States
- Johns Hopkins University — Baltimore, Maryland, United States
- Washington University of St. Louis — St Louis, Missouri, United States
- Beth Israel Hospital — East Hanover, New Jersey, United States
- Montefiore — New York, New York, United States
- University of North Carolina — Chapel Hill, North Carolina, United States
- University Hospital at Cleveland Medical Center — Cleveland, Ohio, United States
- Ohio State University — Columbus, Ohio, United States
- University of Texas (Houston) — Houston, Texas, United States
Full record on ClinicalTrials.gov
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