Mechanisms of Open and Hidden Placebo in Stroke Recovery

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Stroke, Hemiparesis

In brief

This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.

Key facts

Study ID

NCT05832567

Run by

Spaulding Rehabilitation Hospital

People needed

56

Starts

2023-09-11

Expected to finish

2026-12-30

Last updated by the study team

2026-07-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults with hemiparesis due to chronic stroke
• Stroke duration of 6 months or more
• Fugl-Meyer scale upper extremity motor assessment score of > 11 and ≤ 56
• Pre-stroke disability (defined as a score of < 3 on the Modified Rankin Scale)
• Age 18 or older

You may not qualify if…

• Stroke of anterior cerebral artery territory with prefrontal lesion and stroke-related decreased EEG power in the prefrontal cortex
• Unable to understand instructions
• TMS contraindications: electronic hardware in close contact to the discharging coil such as cochlear implant, internal pulse generator or medical pump
• Concurrent unstable medical conditions
• A score of 24 or higher on the Hamilton Depression Rating Scale (HDRS)
• Joint or paretic extremity pain likely to interfere with assessments
• Pregnancy

Where it is running

• Spaulding Hospital Cambridge — Cambridge, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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